Recombinant Human FGF-6 (F121-GRP)

Fibroblast growth factor 6 (FGF6), also known as hst-2 or hst-1-related, is a distinct member of the fibroblast growth factor (FGF) family, which is widely recognized for its roles in cell growth, survival, and diverse biological processes such as embryonic development, tissue repair, and tumor progression. Uniquely, FGF6 expression is predominantly limited to the muscle cell lineage during both development and in adult skeletal muscles, indicating its specialized role in muscle biology. It plays a critical dual role in muscle regeneration by promoting the proliferation and migration of myoblasts as well as enhancing muscle differentiation and hypertrophy in a dose-dependent manner. This key function is linked to its ability to activate satellite cells and regulate myogenic factors, making FGF6 vital for effective muscle repair and growth after injury. This muscle-specific expression and function highlight FGF6 as an essential factor in myogenesis and skeletal muscle regeneration.