Recombinant Human FGF-16 (F125-25ug)

Fibroblast growth factor 16 (FGF-16) is a member of the fibroblast growth factor (FGF) family, which are all heparin-binding growth factors. FGF-16 is most similar to FGF-9 sharing 73% amino acid identity. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-16 is released from neonatal cardiac myocytes and alters growth-related signaling, possibly interfering with cardiac myocyte proliferative potential (2). It lacks a typical signal peptide but is efficiently generated by mechanisms other than the classical protein secretion pathway. FGF-16 signals through the receptors FGFR 2c and 3c (3). It induces proliferation of primary adipocytes and oligodendrocytes in vitro and stimulates liver weight increase in vivo (4).