Recombinant Human Decorin (D333-100ug)

Decorin is a small, ubiquitous cellular or pericellular matrix proteoglycan that belongs to the small leucine-rich proteoglycan (SLRP) family. It has a protein core containing leucine repeats with a glycosaminoglycan chain consisting of either chondroitin sulfate or dermatan sulfate. As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly (1). The decorin core protein also binds to interact with thrombospondin, C1q, EGFR, TGF beta and the decorin endocytosis receptor. It is capable of suppressing the growth and the metastasis of a wide range of cancer cells in vitro through attenuation of the EGFR -mediated intracellular signaling and induction of apoptosis (2). Multiple alternatively spliced transcript variants for the decorin gene have been described. Mutations or deficiency of the decorin gene are associated with Marfan syndrome (3). It is believed that decorin also plays a role in the cell cycle of chondrocytes.