Recombinant Human CD80
Recombinant Human CD80 (B532-GRP)
Products
Description
CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B7-2) to prime T- cells. CD80 binds to CTLA-4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cell-mediated cell death of the CD80 carrier. The activation of Natural Killer cell-mediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | B532 |
| Formulation | This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. |
| Alternate Names | CD80 LAB7 CD28LG CD28LG1 Recombinant Human B7-1 B7-1 B71 B7 1 Recombinant Human B7-1 Recombinant Protein B7-1 CD80 Human B7-1 Recombinant Human B7-1 Recombinant Protein B71 CD80 Human B71 Recombinant Human B71 Recombinant Protein B7 1 CD80 Human B7 1 Recombinant Human B7 1 Recombinant Human B7-1 |
| Target | B7-1 |
| Applications | ELISA Cap |
| Antigen | CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells. |
| Storage | -20°C to -70°C |
| Protein | B7-1 |