Recombinant Human ACE2 (HEK Expressed)
Recombinant Human ACE2 (HEK Expressed) (S856-GRP)
Products
Description
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family1. Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].2 ,or the conversion of angiotensin II to angiotensin 1-7.3 ACE 2 has direct effects on cardiac function3, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.4 ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).5 ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).6
Specifications
| Manufacturer Cat# | S856 |
|---|---|
| Concentration | 0.5 mg/ml |
| Formulation | This recombinant protein is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium, calcium or preservatives added. |
| Target | ACE2 |
| Applications | ELISA |
| Storage | This recombinant protein may be stored as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | ACE2 |