GNF4877 (E7732-1mg)

GNF4877 is an aminopyrazine and a potent inhibitor of GSK3β and DYRK1A with an IC50 of 16 nM and 6 nM, respectively. It blocks nuclear factor of activated T-cells (NFATc) nuclear export, promotes β-cell proliferation, and is useful for research on diabetes drug development.