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Garcinone D

Selleck

Garcinone D (E2794-GRP)

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Description

Garcinone D is a natural xanthone from mangosteen, an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 with an IC50 of 28.23 μM. It promotes neural stem cell proliferation via STAT3 and Nrf2/HO-1 activation while inhibiting prostate and breast cancer growth by blocking the CDK2/CyclinE1-mediated cell cycle and can be used in prostate and breast cancer research.

Specifications

Manufacturer Cat# E2794
Target STAT