FG-7142 (S0789-25mg)

FG-7142 (ZK 39106, LSU-65) is a non-selectively benzodiazepine inverse agonist with Ki of 91 nM for the α1 subunit-containing GABAA receptor. FG-7142 also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit with EC50 of 137 nM). FG-7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex.