FAZ-3532 (E5928-GRP)

FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study the immunological role of stress granules during viral infection.