Epibetulinic acid (S5890-GRP)

Epibetulinic acid is a natural product isolated from the root bark of Maytenus cuzcoina and the leaves of Maytenus chiapensis with anti-inflammatory activity. Epibetulinic acid inhibits NO and prostaglandin E2 (PGE2) production in mouse macrophages stimulated with bacterial endotoxin with IC50 of 0.7 μM and 0.6 μM, respectively.