Enoximone (S0891-GRP)

Enoximone, an inotropic vasodilating agent, is a selective, orally active inhibitor of phosphodiesterase III (PDE3) with IC50 of 5.9 μM. Enoximone induces vasodilatation and increases intracellular levels of cAMP by inhibiting cGMP-inhibited PDE. Enoximone also inhibits PDE4 with IC50 of 21.1 μM for myocardial PDE4A.