DDD85646 (E5974-GRP)

DDD85646 (IMP-366) is an orally active inhibitor of N-myristoyltransferase(NMT), with an IC50 of 2 nM for Trypanosoma brucei NMT (TbNMT) and 4 nM for human NMT (hNMT). It exhibits a potential for treating human African trypanosomiasis.