CORM-401 (E6435-GRP)

CORM-401 is a water-soluble Carbon monoxide-releasing molecule that exhibits antioxidant and cytoprotective effects under oxidative stress conditions, including TNF-α/CHX and H₂O₂-induced damage. It induces nitric oxide production, activates the pentose phosphate pathway, and triggers distinct calcium signaling patterns, contributing to the regulation of endothelial function.