CIM0216 (E0390-GRP)

CIM0216 is a synthetic TRPM3 ligand that functions as a TRPM3 agonist. It shows preference for TRPM3 compared to TRPM1, TRPM2, and TRPM4-8. In vitro studies demonstrate that CIM0216 operates through TRPM3 to trigger pain responses and stimulate neuropeptide release from sensory nerve endings. This compound serves as a valuable research tool for investigating TRPM3's physiological roles and studying neurogenic inflammation.