CDr17 M1 Macrophage Stain (5292-1mg)

CDr17 is a selective small-molecule fluorescent probe designed for the identification and tracking of M1 macrophages. The labeling method is based on the higher expression of the GLUT1 transporter in M1 (pro-inflammatory) macrophages compared to M0 (resting) and M2 (anti-inflammatory) macrophages. CDr17 probe is composed of a glucose scaffold and a 2-position Cyanine5 fluorophore, and due to this, it is taken up into cells specifically through the GLUT1 transporter. The CDr17 accumulation is directly proportional to GLUT1 expression levels. CDr17 has been demonstrated to track M1 macrophages in vivo in a rheumatoid arthritis animal model [1].