BIO-2007817 (E5771-GRP)

BIO-2007817 is a tetrahydropyrazolo-pyrazine and a positive allosteric modulator(PAM) that can act as a molecular glue to enhance the ability of pUb to activate Parkin with an EC50 of 150 nM. It can be used in research design of activators as therapeutics for Parkinson’s disease.