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Avagacestat (BMS-708163)

Avagacestat (BMS-708163) (S1262-GRP)

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Description

Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Specifications

Manufacturer Selleck Chemicals LLC
Manufacturer Cat# S1262
Target Beta Amyloid