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Auristatin E

Auristatin E (S0561-GRP)

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Description

Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G₂/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity.

Specifications

Manufacturer Selleck Chemicals LLC
Manufacturer Cat# S0561
Target Others