Anti-UVRAG Antibody (23013) (23013-100ug)

Autophagy is a catabolic process that results in the degradation of bulk cytoplasmic contents within autophagosomes and lysosomes. UV radiation resistance-associated gene product (UVRAG) is a protein localized in the endoplasmic reticulum (ER) and endosomes and is known to regulate autophagosome maturation as well as early stages of autophagy. UVRAG regulates autophagosome maturation by binding to the homotypic fusion and vacuole protein sorting (HOPS) complex, which consists of the class C Vps complex (Vps11-Vps16-Vps18-Vps33) and two additional proteins, Vps39 and Vps41. UVRAG binding to the HOPS complex stimulates lysosomal fusion with autophagosome and endosome.