USP5 antibody
£227.50
USP5 antibody (FNab09340)
Product
| Cat # FNab09340 | Size 100ug |
Price
£227.50
|
Qty
|
Description
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Specifications
| Manufacturer Cat# | FNab09340 |
|---|---|
| Product Size | 100ug |
| Antibody Type | Polyclonal |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Physical Appearance | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | ubiquitin specific peptidase 5(isopeptidase T) |
| Alternate Names | Ubiquitin carboxyl-terminal hydrolase 5|Deubiquitinating enzyme 5|Isopeptidase T|Ubiquitin thioesterase 5|Ubiquitin-specific-processing protease 5|USP5|ISOT |
| Calculated MW | 93 kDa |
| Protein ID | P45974 |
| Reactivity | Human, Mouse, Rat |
| Applications | ELISA, WB |
| Recommended dilution | WB: 1:1000-1:2000 |
| Gene ID | 8078 |