Anti-TNF Receptor 1 (11062-GRP)

Tumor necrosis factor alpha (TNF-α), also known as cachectin, is a 157-amino acid cytokine (~17.5 kDa) and a prominent member of the TNF superfamily. TNF-α is a key immunomodulatory molecule with potent proinflammatory effects across a broad spectrum of target cells. It is synthesized primarily by macrophages, natural killer (NK) cells, and activated T and B lymphocytes, and exists in both soluble and membrane-bound trimeric forms. TNF-α initiates signaling by binding to two distinct receptors: 1.) TNF receptor 1 (TNF-R1), which is broadly expressed on most normal and malignant cells 2.) TNF receptor 2 (TNF-R2), found primarily on endothelial cells and immune cells Upon receptor binding and trimerization, TNF-α triggers a cascade of signaling pathways that regulate critical biological processes including hematopoiesis, cell differentiation, apoptosis, lipid metabolism, endothelial activation, tumor development, and immune surveillance. Aberrant TNF-α signaling is associated with a wide range of pathologies, such as autoimmune diseases, cancer, osteoporosis, atherosclerosis, and type 2 diabetes. This TNF Receptor 1 Polyclonal Antibody is great for Immunohistochemistry and enables precise detection of TNF-R1 expression patterns in tissue samples, aiding in the study of inflammatory responses, tumor microenvironments, and TNF-α–mediated signaling pathways in both normal and diseased states.