Anti-Tau Antibody (57013) (57013-100ug)

Tau is a subunit protein of one of the major markers of Alzheimer disease (AD), the neurofibrillary tangles. Tau protein has many unusual properties, such as its number of structural conformations and biochemical modifications (phosphorylation, proteolysis, and glycosylation), and its many interaction partners (mainly microtubules, but also other cytoskeletal proteins, kinases, and phosphatases, motor proteins, chaperones, and membrane proteins). The aggregation of Tau is toxic in cell and animal models, but can be reversed by suppressing expression or by aggregation inhibitors.