Anti-RSK1 Reactive with Human, Rat and Mouse (R1261-GRP)

Ribosomal protein S6 Kinase 1 (RSK1) is a member of the RSK family that consists of growth factor-regulated serine/threonine kinases. RSK1 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. RSK1 encodes a predicted 735 amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue. RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation.