Anti-Rat ICAM-1 (Clone 141011)
Anti-Rat ICAM-1 (Clone 141011) (I-682-GRP)
Products
Description
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
Specifications
| Manufacturer Cat# | I-682 |
|---|---|
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Intercellular Adhesion Molecule 1 BB2 CD54 P3.58 141011 ICAM-1 Rat Anti-Rat ICAM-1 |
| Isotype | IgG2a |
| Clone | 141011 |
| Antibody Type | Monoclonal |
| Applications | ELISA Indirect, WB |
| Antigen | CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes. |
| Storage | -20°C to -70°C |
| Protein | ICAM-1 |