Anti-Rat CD4 (Clone OX-38) - Purified <i>in vivo </i>PLATINUM™ Functional Grade (C753-GRP)

CD4 is a 55 kD single-chain type I transmembrane glycoprotein with four domains and is a member of the Ig superfamily1,2. CD4 functions primarily as a coreceptor for the MHC class II molecule-peptide complex and initiates the early phase of T-cell activation via its association with the T-cell receptor complex and protein tyrosine kinase Lck3. In addition, CD4 T lymphocytes are essential to the host response against infectious disease4 and CD4 T cells mediate neuronal damage in infectious and immune-mediated diseases of the central nervous system5. In macrophages and natural killer cells, CD4 plays a role in differentiation/activation, cytokine expression and cell migration3. OX-38 was generated by immunizing mice with lymphocytes or thymocyte glycoproteins and subsequently fusing mouse spleen cells with the P3-X63/Ag 8 cell line6. OX-38 is a depleting monoclonal antibody used to study tolerance to allografts7,8,9,10,11 , Pneumocystis-host interaction4, and alopecia12 in rat models.