Anti-p53 Antibody (3347) (3347-100ug)

Tumor protein p53, also known as p53, functions as a tumor suppressor, and, as such, p53 has been described as “the guardian of the genome†because of its role in preventing genome mutations. The name p53 describes the apparent molecular mass of the protein as observed in SDS-PAGE analysis. The actual mass of full-length p53, based on the sum of masses of the amino acid residues, is 43.7kDa. The difference is due to the number of proline residues in the protein which slow its migration on SDS-PAGE, thus making it appear heavier than it actually is. The TP53 gene is the most frequently mutated gene (>50%) in human cancer.