Anti-p38α MAP Kinase Antibody (56450) (56450-100ug)

The MAPKs (Mitogen-Activated Protein Kinases) are protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. Upon activation, p38alpha MAPK translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. p38alpha MAPK is activated by chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, lipopolysaccharide, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs.