anti- P21 antibody
£245.00
anti- P21 antibody (FNab06066)
Product
| Cat # FNab06066 | Size 100µg |
Price
£245.00
|
Qty
|
Description
CDKN1A(p21, CIP1, WAF1), a cyclin-dependent kinase inhibitor, is necessary for proper control of the cell cycle and premature senescence. P21 is a cyclin-dependent kinase(CDK) inhibitor that suppresses proliferation by inhibiting CDK2 and CDK1 activity at the G1/S and G2/M transitions. P21 is a major mediator of p53 to induce cell cycle arrest in G1. p21 can interact with proliferating cell nuclear antigen(PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. P21 was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Overexpression of p21 decreases the expression levels of cell cycle progression genes and upregulates senescence-inducing genes.
Specifications
| Product Size | 100µg |
|---|---|
| Antibody Type | Monoclonal |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Physical Appearance | liquid |
| Purification | Protein A+G purification |
| Purity | ≥95% as determined by SDS-PAGE |
| Host | Mouse |
| Isotype | IgG1 |
| Immunogen | cyclin-dependent kinase inhibitor 1A(p21, Cip1) |
| Alternate Names | CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1 |
| Calculated MW | 21 kDa |
| Protein ID | P38936 |
| Clone | 8E0 |
| Reactivity | Human |
| Applications | ELISA, WB |
| Recommended dilution | WB: 1:500-1:2000 |
| Gene ID | 1026 |