Anti-Norovirus, Capsid (Clone NORO-313) - Purified No Carrier Protein (N266-GRP)

Norovirus is a highly contagious pathogen known for its ability to cause acute gastroenteritis, which is a major health concern worldwide1. The virus's low infectious dose means minor exposure can lead to infection. Prolonged shedding by hosts and environmental resilience further heighten transmission risks through prolonged surface contamination2. It is the leading cause of foodborne diseases, exclusively infecting humans3. Timely implementation of infection prevention measures is crucial for outbreak control2. Studies have found a variety of antibodies that have a broad reactivity for noroviruses, including single-chain antibodies4, monoclonal antibodies5, and a cross-reactive monoclonal antibody6. These antibodies have the potential to be used in diagnostic applications as they have been shown to detect norovirus antigens in clinical samples. Studies have also found that the reactivity of these antibodies can vary depending on the norovirus strain7. NORO-313 is a human monoclonal antibody with broad cross-reactivity and the capability to neutralize multiple genotypes of norovirus, highlighting its significant potential in the development of norovirus vaccines and diagnostic tools. It targets a highly conserved region in the P-domain of the norovirus capsid protein, suggesting its neutralization mechanism might involve steric hindrance through multivalent cross-linking. This clone's ability to recognize and neutralize diverse norovirus strains, including both GI and GII genogroups, underscores its importance in advancing our understanding and control of norovirus infections8.