Anti-Mouse TNFα - DyLight® 488
Anti-Mouse TNFα - DyLight® 488 (T618-GRP)
Products
Description
TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α binding to surface receptors brings about various biologic activities that include cytolysis and cytostasis of many tumor cell lines In vitro, hemorraghic necrosis of tumors In vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T618 |
| Concentration | 0.2 mg/ml |
| Formulation | This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | Monoclonal Antibody Tumor Necrosis Factor-α TNFSF2 Cachectin Differentiation-Inducing Factor (DIF) Necrosin Cytotoxin TN3-19.12 TNF-α Mouse Anti-Mouse TNFα - DyLight® 488 |
| Isotype | IgG |
| Clone | TN3-19.12 |
| Target | TNF-α |
| Antibody Type | Monoclonal |
| Applications | FC |
| Antigen | TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, B cells, NK cells, LAK cells. |
| Storage | This DyLight® 488 conjugate is stable when stored at 2-8 degrees C. Do not freeze. |
| Protein | TNF-α |