Info
01480 839 015

  • awesomeicons6/solid/lock 100% Secure Online Payments

Anti-Mouse LPAM-1 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade

Anti-Mouse LPAM-1 - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (L307-GRP)

Leinco Technologies Inc
Contact us about this product

Products

Sort by arrow-down-short-wide arrow-up-short-wide
Cat #
Size
Price
Cat # Size
chevron-left chevron-right
of

Description

LPAM-1 antibody, clone DATK32, recognizes mouse lymphocyte Peyer’s patch adhesion molecule (LPAM-1), also known as integrin alpha 4 beta 7 (α4β7). LPAM-1 is a heterodimer of the 154 kDa integrin α4 (CD49d) and 130 kDa integrin β7 chains and is a member of the Ig superfamily. LPAM-1 is expressed on most peripheral lymphocytes, subsets of thymocytes, and bone marrow hematopoietic stem cells1,2. LPAM-1 mediates adhesion to endothelial cells, promoting leukocyte transmigration across high endothelial venules (HEVs) during the inflammatory response. LPAM-1 binds to several ligands, including vascular adhesion molecule-1 (VCAM-1/CD106), mucosal addressin cell adhesion molecule-1 (MAdCAM-1), and fibronectin. MAdCAM-1 is expressed exclusively on endothelial cells of the gut and gut-associated lymphoid tissues, such as Peyer’s patches (PPs), and binding of LPAM-1 to MAdCAM-1 contributes to lymphocyte homing to mucosal tissues3,4. Vedolizumab, an anti-LPAM-1 monoclonal antibody, is approved to treat inflammatory bowel disease and effectively induces and maintains remission in Crohn's disease and ulcerative colitis5-8.

Specifications

Manufacturer Leinco Technologies Inc
Manufacturer Cat# L307
Concentration ≥ 5.0 mg/ml
Formulation This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Isotype IgG2a κ
Clone DATK32
Target LPAM-1
Antibody Type Monoclonal
Applications B, FC, IHC FF, in vivo, IP
Antigen LPAM-1 is expressed on most peripheral lymphocytes, subsets of thymocytes, and bone marrow progenitor cells.
Storage Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Protein LPAM-1