Anti-Mouse Jagged 2 - Purified <i>in vivo </i>GOLD™ Functional Grade (J131-GRP)

The Notch pathway is an intercellular signaling mechanism that controls cell fate and differentiation during embryonic and postnatal development1,2,3. The pathway is highly conserved across species. Four mammalian Notch receptors (Notch 1-4) have been identified and can be activated by their ligands Jagged1, Jagged2, DLL1, DLL3, or DLL4. These ligands are transmembrane proteins that contain a Delta/Serrate/Lag-2 extracellular domain that is used for interactions with the Notch receptors3. Receptor-ligand engagement triggers cleavage of the Notch receptor extracellular domain, leading to the release of the Notch intracellular domain which travels to the nucleus and affects target gene expression. Dysregulation of Notch signaling affects inflammation3 as well as tumorigenesis and cancer growth1,4. HMJ2-1 was generated using CHO cells expressing murine Jagged25.