Anti-Mouse IL-2 (Clone: JES6-1A12) - Purified <i>in vivo </i>GOLD™ Functional Grade
£112.50
Anti-Mouse IL-2 (Clone: JES6-1A12) - Purified <i>in vivo </i>GOLD™ Functional Grade (I-1042-0.5mg)
Product
| Cat # I-1042-0.5mg | Size 0.5 mg |
Price
£112.50
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Qty
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Description
IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-1042 |
| Product Size | 0.5 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody Interleukin-2 TCGF Lymphokine T-Cell Growth Factor Aldesleukin JES6-1A12 IL-2 Mouse Anti-Mouse IL-2 - Purified Low Endotoxin Functional Formulation |
| Isotype | IgG2a κ |
| Clone | JES6-1A12 |
| Target | IL-2 |
| Antibody Type | Monoclonal |
| Applications | in vivo, IP, N, WB |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | IL-2 |