Anti-Mouse IL-1R (CD121a) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
£98.44
Anti-Mouse IL-1R (CD121a) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (I-435-1.0mg)
Product
| Cat # I-435-1.0mg | Size 1.0 mg |
Price
£98.44
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Qty
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Description
IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1α and IL-1ß exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1ß, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-435 |
| Product Size | 1.0 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody Interleukin-1 R1 Interleukin-1 R1 JAMA-147 IL-1 R1 Mouse Anti-Mouse Interleukin-1 R1 Type 1 Low Endotoxin Functional Formulation |
| Isotype | IgG |
| Clone | JAMA-147 |
| Target | Interleukin-1 R |
| Antibody Type | Monoclonal |
| Applications | B, in vivo, IP, WB |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | Interleukin-1 R |