Anti-Mouse IL-12 - Purified In vivo GOLDâ„¢ Functional Grade
Anti-Mouse IL-12 - Purified In vivo GOLDâ„¢ Functional Grade (I-1175-GRP)
Products
Description
IL-12 plays a role in resistance against pathogens via the differentiation of naive T cells into Th1 cells. It stimulates the growth and function of T cells, blocks formation of new blood vessels, and contributes to antimycobacterial immune response. In addition, it promotes the production of IFN-γ and TNF-α and reduces IL-4 mediated suppression of IFN-γ. Consequently, this enhances the immunostimulatory and immunomodulatory effects of IFN-γ. In addition, there appears to be a link between IL-2 and the signal transduction of IL-12 in NK cells, which enhances the functional response of IL-12 via IFN-γ production and killing of target cells. Furthermore, IL-12 is thought to be associated with autoimmunity. IL-12 was shown to worsen the condition when administered to people already suffering from autoimmune diseases. Comparatively, inhibition of IL-12 (either through IL-12 gene knock-out in mice or treatment of mice with IL-12 mAbs) improved the disease.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | I-1175 |
| Concentration | ≥ 2.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody Interleukin-12 NKSF TSF Maturation Factor Cytotoxic Lymphocyte Maturation Factor (CLMF) p35 C17.8 IL-12 Mouse Anti-Mouse IL-12 Purified Low Endotoxin Functional Formulation |
| Isotype | IgG2a κ |
| Clone | C17.8 |
| Antibody Type | Monoclonal |
| Applications | ELISA, ICFC, IP, N, WB |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | IL-12 |