Anti-Mouse Fas Ligand (Clone 101624)
Anti-Mouse Fas Ligand (Clone 101624) (F1074-GRP)
Products
Description
Fas ligand (FasL) is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation. FasL is regarded as a potential target for immunotherapy.1
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | F1074 |
| Formulation | This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present. |
| Alternate Names | Monoclonal Antibody Fas Ligand TNFSF6 CD95L Apo I Ligand APTL FASLG APT1LG1 CD178 101624 Mouse Anti-Mouse Fas Ligand |
| Isotype | IgG1 |
| Clone | 101624 |
| Target | Fas Ligand |
| Antibody Type | Monoclonal |
| Applications | N, WB |
| Storage | -20°C to -70°C |
| Protein | Fas Ligand |