Anti-Mouse CD8a (Ly 2) - Purified (PhenoCyler-Fusion (CODEX)® Ready)
£89.06
Anti-Mouse CD8a (Ly 2) - Purified (PhenoCyler-Fusion (CODEX)® Ready) (C514-50ug)
Product
| Cat # C514-50ug | Size 50 µg |
Price
£89.06
|
Qty
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Description
CD8 is made up of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8 is part of the Ig superfamily that expresses primarily as CD8a homodimers. CD8a is a 32-34 kD type I glycoprotein that can also form heterodimers with CD8b. CD8 is an antigen co-receptor on T cells that mediates efficient cell to cell interactions within the immune system. CD8 coupled with the T cell receptor on the T lymphocyte recognizes an antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The CD8 co-receptor also plays a role in T cell signaling by interacting with Lck (lymphocyte-specific protein tyrosine kinase) which leads to the activation of transcription factors that affect the expression of certain genes.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C514 |
| Product Size | 50 µg |
| Concentration | 0.5 mg/ml |
| Formulation | This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4. |
| Clone | 53-6.7 |
| Target | CD8a |
| Applications | IHC FF, PhenoCycler® |
| Antigen | Lyt 2 is present on the surface of most thymocytes and a subpopulation of mature T-lymphocytes which include most T suppressor/cytotoxic cells. |
| Storage | This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD8a |