Anti-Mouse CD80 - Purified
£195.94
Anti-Mouse CD80 - Purified (C2044-500ug)
Product
| Cat # C2044-500ug | Size 500 µg |
Price
£195.94
|
Qty
|
Description
CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B7-2) to prime T- cells. CD80 binds to CTLA-4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cell-mediated cell death of the CD80 carrier. The activation of Natural Killer cell-mediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C2044 |
| Product Size | 500 µg |
| Concentration | 0.5 mg/ml |
| Formulation | This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | Monoclonal Antibody CD80 B7-1 BB1 16-10A1 Mouse Anti-Mouse CD80 (B7-1) Purified Flow Cytometry Immunohistochemistry Immunoprecipitation Immunology B7-1 BB1 B71 Ly-53 Ly53 |
| Isotype | IgG |
| Clone | 16-10A1 |
| Target | B7-1 |
| Antibody Type | Monoclonal |
| Applications | FC, IHC FFPE, IP |
| Antigen | CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells. |
| Storage | This purified antibody is stable when stored at 2-8°C. Do not freeze. |
| Protein | B7-1 |