Anti-Mouse CD80 - DyLight® 488
Anti-Mouse CD80 - DyLight® 488 (C2243-GRP)
Products
Description
CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B7-2) to prime T- cells. CD80 binds to CTLA-4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cell-mediated cell death of the CD80 carrier. The activation of Natural Killer cell-mediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C2243 |
| Concentration | 0.2 mg/ml |
| Formulation | This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | Monoclonal Antibody CD80 B7-1 BB1 B71 Ly-53 Ly53 16-10A1 Mouse Anti-Mouse CD80 (B7-1) - DyLight® 488 Immunology B71 Ly-53 Ly53 CD152 CTLA-4 CD28 CD86 Flow Cytometry DyLight 488 |
| Isotype | IgG |
| Clone | 16-10A1 |
| Target | B7-1 |
| Antibody Type | Monoclonal |
| Applications | FC, ICC |
| Antigen | CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells. |
| Storage | This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. |
| Protein | B7-1 |