Anti-Mouse CD8 (Lyt 2.1) [Clone 116-13.1] - Purified <i>in vivo</i> PLATINUM™ Functional Grade (C3111-25mg)

CD8 is an integral membrane protein essential to the immune response1. CD8 acts as a co- receptor for the MHC class I molecule:peptide complex and recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex, leading to activation of cytotoxic T-lymphocytes which recognize and eliminate infected cells and tumor cells. CD8+ T cell differentiation is tightly regulated and the T cell response depends on the antigen encountered. The immune response to acute infection, autoimmunity, graft vs host disease, tumors, chronic infection, and self-tolerance are all affected by CD8 + T cells2. 116-13.1 is commonly used for the depletion of CD8+ T cells, such as in studies on allotransplantation tolerance3,4,5, CD8+ T cell-mediated antitumor immune response during cancer immunotherapy6, induction of MHC-mismatched mixed chimerism in NOD mice for the therapy of type I diabetes7, and to better understand the development of autoimmune thyroid disease8. Such depletion studies have shown, for example, that CD8+ T lymphocytes play a role in graft rejection via an indirect pathway4. 116-13.1 was first described in Monoclonal Antibodies and T-Cell Hybridomas published in 19839.