Anti-Mouse CD73 - Purified <i>in vivo </i>GOLD™ Functional Grade (C2413-GRP)

CD73 is a 69 kDa cell-surface protein anchored to the membrane by a GPI (glycosylphosphatidylinositol) anchor. CD73 plays a vital role in modulating the immune response by converting AMP (adenosine monophosphate) to adenosine. This conversion shifts the environment from being pro-inflammatory to anti-inflammatory. CD73 is particularly involved in the immunosuppressive activity of regulatory T cells. It catalyzes the dephosphorylation of extracellular nucleoside 5' monophosphates to nucleosides1,2. CD73 is expressed on specific subsets of T and B lymphocytes, with the highest expression found on B cells and CD8+ T cells. It is also implicated in cell activation, lymphocyte homing, and cell adhesion3. Moreover, CD73 has protective functions in various organ systems and cell types. For instance, it plays anti-nociceptive roles in the central nervous system and barrier-preserving roles in the respiratory system4. The TY/23 clone has been demonstrated to inhibit the enzymatic activity of CD73. Therefore, it is a valuable tool for studying the role of CD73 in immune regulation and its potential as a therapeutic target5. This clone has been utilized for both in vivo and in vitro CD73 blockade, contributing significantly to our understanding of how CD73 impacts immune responses and tumor microenvironments6. CD73 is a key player in the tumor microenvironment, and inhibiting its activity has been suggested as a potential strategy for cancer immunotherapy7. Tumors exploit CD73 to generate adenosine, which then suppresses T-cell responses against the tumor. By targeting CD73 and inhibiting its function, it is believed that tumorigenesis can be reduced, and T-cell-directed therapies can be enhanced8.