Anti-Mouse CD4 (Clone YTS191) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
Anti-Mouse CD4 (Clone YTS191) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C3220-GRP)
Products
Description
CD4 antibody, clone YTS191, recognizes CD4, a 58 kDa type I transmembrane glycoprotein of the Ig superfamily. CD4 is expressed by the majority of thymocytes, MHC class II-restricted T cells (helper T cells and immunosuppressive regulatory T cells), and subsets of natural killer T (NKT) cells, dendritic cells (DCs) and macrophages1-3. On T cells, CD4 is a co-receptor of the T cell receptor (TCR) and interacts with major histocompatibility complex (MHC) II molecules on antigen-presenting cells (APCs). CD4 contributes to T cell development and selection and enhances TCR-dependent signaling by up to 100-fold through the accumulation of Lck4-6. CD4 also contributes to the activation of NKT, macrophages, and DCs7,8.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C3220 |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Clone | YTS191 |
| Applications | Depletion, FC, IHC FF, WB |
| Antigen | CD4 is expressed on most thymocytes, MHC class II-restricted T cells, a subset of NKT cells, and subsets of dendritic cells and macrophages. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD4 |