Anti-Mouse CD370 (CLEC9A/DNGR1) - Purified In vivo GOLD™ Functional Grade

CLEC9A antibody, 1F6, recognizes C-type lectin domain family 9 member A (CLEC9A), also known as CD370 and DNGR-1. CLEC9A is a type II transmembrane glycoprotein that belongs to the C-type lectin superfamily. In mice and humans, CLEC9A is expressed by CD8a+ conventional dendritic cells (cDCs) in mice1,2 and BDCA3+ DCs in humans3, which are specialized for the cross-presentation of exogenous antigens on MHC class I4. In mice, type I interferon (IFN)-secreting plasmacytoid DCs (pDCs) also express CLEC9A2. The ligand for CLEC9A is filamentous actin exposed on apoptotic cells5,6, and ligation of CLEC9A results in the cross-presentation and induction of CD8 T cell responses. CLEC9A is a target for vaccine enhancement, and antibodies targeting CLEC9A in vaccination studies lead to enhanced presentation by DCs, eliciting CD8 and CD4 T cell proliferation and strong humoral immunity
Cat# Size Price Qty Buy
I-2001-100mg 100 mg
£2,156.25
I-2001-50mg 50 mg
£1,495.31
I-2001-25mg 25 mg
£904.69
I-2001-5.0mg 5.0 mg
£332.81
I-2001-1.0mg 1.0 mg
£98.44

Additional Information

Property Value or Rating
Manufacturer Cat# I-2001
Concentration ≥ 5.0 mg/ml
Formulation This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Manufacturer Leinco Technologies Inc
Clone 1F6
Applications FC, IF, WB
Antigen CD370 (CLEC9A) in mice is expressed on CD8+ DCs and at low levels by plasmacytoid DCs
Storage Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Protein CD370

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