Anti-Mouse CD32/CD16 - Purified <i>in vivo </i>PLATINUMâ„¢ Functional Grade
Anti-Mouse CD32/CD16 - Purified <i>in vivo </i>PLATINUMâ„¢ Functional Grade (C681-GRP)
Products
Description
CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C681 |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Isotype | IgG2b |
| Clone | 2.4G2 |
| Target | CD32/CD16 |
| Applications | B, FA, FC, IHC FF, in vivo, IP, PhenoCycler®, WB |
| Antigen | These receptors are present on B cells, monocyte/macrophages, NK cells, neutrophils, mast cells and dendritic cells. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD32/CD16 |