Anti-Mouse CD278 (ICOS) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
Anti-Mouse CD278 (ICOS) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C2258-GRP)
Products
Description
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C2258 |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Isotype | IgG2b κ |
| Clone | 7E.17G9 |
| Target | CD278 |
| Antibody Type | Monoclonal |
| Applications | B, FA, FC, in vivo, WB |
| Antigen | ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD278 |