Anti-Mouse CD275 - Purified <i>in vivo </i>PLATINUMâ„¢ Functional Grade
Anti-Mouse CD275 - Purified <i>in vivo </i>PLATINUMâ„¢ Functional Grade (C2448-GRP)
Products
Description
ICOSL, also known as CD275 and B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains. ICOSL is expressed on B cells and macrophages. It binds to ICOS on activated T cells and thus delivers a positive costimulatory signal for optimal T cell function1. ICOS and B7RP-I do not interact with proteins in the CD28-B7 pathway2. The structural features of ICOSL are crucial for its costimulatory function. ICOSL constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein3.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C2448 |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This Monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Clone | HK5.3 |
| Target | B7-H2 |
| Applications | B, FC, in vivo, N |
| Antigen | splenic B-cells, T-cells, dendritic cells and macrophages |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -70°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | B7-H2 |