Anti-Mouse CD18 (Clone C71/16) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade
£98.44
Anti-Mouse CD18 (Clone C71/16) - Purified <i>in vivo </i>GOLDâ„¢ Functional Grade (C378-1.0mg)
Product
| Cat # C378-1.0mg | Size 1.0 mg |
Price
£98.44
|
Qty
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Description
CD18 is a 95kD type I transmembrane glycoprotein. CD18 is the Integrin β2 chain and forms multiple heterodimers with the three integrin α chains, CD11a, CD11b, and CD11c. CD18 binds with CD11a to form LFA-1. LFA-1 is involved in adhesion and binding to antigen presenting cells via interactions with ICAM-1. CD18 binds with CD11b and CD11c forming complement receptors , such as MAC-1, that participate in the innate immune response by recognizing foreign antigen peptides and destroying them via phagocytosis. In humans, lack of functional CD18 causes Leukocyte Adhesion Deficiency (LAD) which is characterized by the inability of circulating leukocytes to respond to foreign bodies, reducing the ability of the immune system to fight off infection.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | C378 |
| Product Size | 1.0 mg |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Alternate Names | Monoclonal Antibody CD18 LFA-1 Integrin β2 Chain C71/16 Mouse Anti-Mouse CD18 (LFA-1 Integrin β2 Chain) Purified Low Endotoxin Functional Formulation |
| Isotype | IgG2a |
| Clone | C71/16 |
| Target | CD18 |
| Antibody Type | Monoclonal |
| Applications | FA, in vivo, IP, WB |
| Antigen | The mouse CD18 antigen is present on mouse T-cells, B-cells, NK cells, monocytes, macrophages and granulocytes. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | CD18 |