Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488
Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488 (T627-GRP)
Products
Description
Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T627 |
| Concentration | 0.2 mg/ml |
| Formulation | This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. |
| Alternate Names | Monoclonal Antibody Tumor Necrosis Factor Receptor II TNFRSF1B p75 CD120b TBPII TNF-R75 TNFBR TNFR2 TNFR80 p75TNFR TR75-54.7 TNF RII Mouse CD120b Anti-Mouse TNF RII |
| Isotype | IgG |
| Clone | TR75-54.7 |
| Target | TNFR2 |
| Antibody Type | Monoclonal |
| Applications | FC |
| Storage | This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. |
| Protein | TNFR2 |