Anti-Mouse CD120a (TNFR1) (Clone 55R-170) - Purified <i>in vivo </i>PLATINUMâ„¢ Functional Grade
Anti-Mouse CD120a (TNFR1) (Clone 55R-170) - Purified <i>in vivo </i>PLATINUMâ„¢ Functional Grade (T950-GRP)
Products
Description
Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-α and TNF-ß (also known as LT-α). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein).
Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.
Specifications
| Manufacturer | Leinco Technologies Inc |
|---|---|
| Manufacturer Cat# | T950 |
| Concentration | ≥ 5.0 mg/ml |
| Formulation | This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. |
| Isotype | IgG |
| Clone | 55R-170 |
| Target | TNFR1 |
| Applications | B, ELISA, FC, in vivo, IP, WB |
| Antigen | CD120a is constitutively expressed in most tissues. |
| Storage | Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. |
| Protein | TNFR1 |