Anti-Mouse CD106 (VCAM-1) (Clone M/K-2.7) - Purified in vivo GOLD™ Functional Grade (C2491-GRP)

CD106 is a single-chain type I glycoprotein with a molecular weight of 110 kDa. It is upregulated in response to inflammatory stimuli and cytokines, and it plays an important role in leukocyte adhesion, transmigration, and T-cell proliferation by binding to integrins CD49d/CD29 (VLA-4) and α4β71. It has implications in several pathologies, including heart diseases, inflammation, and cancer metastasis2. The regulation and function of CD106 in immune responses highlight its potential as a therapeutic target in treating these conditions. The M/K-2.7 clone was developed using stromal cells derived from mouse bone marrow as the immunogen. It has been widely used in various research contexts, particularly in studies involving in vivo VCAM-1 neutralization, immunofluorescence techniques, and more. This clone demonstrates its versatility across a range of experimental setups and is a valuable tool for investigating vascular cell adhesion mechanisms and the inflammatory process. It is particularly useful for research focused on inflammatory processes, immune cell migration, and the study of vascular biology3-6.